My son was born several months premature. I remember hoping that he would not have to endure a life of suffering and torment. After nine days of fighting for his life, he had nothing left and passed away. The guilt that I have felt ever since is exactly what this song is about.
Eric Clapton blamed himself for his son's death and that is what this song is about. It's about a parent that feels responsible for their child's death.
I hope none of you ever feel the pain he felt while writing this song, it overshadows any loss you've experienced.